GASTRIC CANCER PREVENTION IN OCCUPATIONAL DISEASES

Abstract

Objectives. Establishing the importance of non-invasive serological diagnosis of precancerous gastric lesions in the early detection of gastric cancer, in order to reduce the risk of its occurrence, especially in professionally compromised patients.

Material and methods. We analyzed 29 cases with precancerous gastric lesions. All patients were examined endoscopically Narrow-band imaging + 5 biopsies, guided according to the Sydney protocol and examined histologically according to the OLGA/OLGIM classification. They were also investigated serologically, using the Gastro-Panel test: Pepsinogen (PG) I, PGII, PGI/PGII ratio, Gastrin (G)-17 and H. pylori IgG.

Results. Out of the 29 cases, 11 cases of OLGA I-II atrophy and 9 cases of OLGA III-IV, OLGIM I-II – 3 cases, OLGIM III-IV – 1 cases, 5 cases with dysplasia were determined. In 75% of subjects gastric atrophy was located in the antrum, 16% – in the body and 8% – diffuse. In 4 cases, the endoscopic examination did not coincide with the histological examination (being cancers de novo). 79% of subjects with severe atrophy OLGA III-IV or OLGIM III-IV, serological tests confirmed the morphological degree obtained: PG-I≤30 μg /L and PG-I/II≤2, and in 63% of cases with atrophic antral located gastritis, the G-17 indicator <1 µg / L was present.

Conclusion. Gastric cancer remains an important medical and social problem. Non-invasive serological diagnosis involving PGI, PGI/PGII and G-17 indicators could improve the early detection of gastric cancer, especially in those with occupational risk factors.