SENSITIVITY TO ANTIBIOTICS OF STAPHYLOCOCCUS AUREUS STRAINS ISOLATED FROM WOUND INFECTIONS

Abstract

Introduction. Wound infection, caused by Staphylococcus aureus, is frequently encountered in medical practice. Knowing the resistance phenotypes, respectively the sensitivity to antibiotics of circulating strains, as well as the emergence of methicillin-resistant strains, motivates the purpose of this study as a support for the initiation of appropriate early therapy.

Material and methods. The sensitivity to antibiotics of 183 strains of Staphylococcus aureus, isolated from wound infections, was analyzed. Bacterial identification was performed using the Vitek 2 Compact system. Sensitivity to antibiotics was tested by the diffusimetric method and the Vitek 2 Compact system.

Results. Out of the 183 strains tested, 108 (59.0%) were methicillin-resistant, 75 (41.0%) methicillin-sensitive. To macrolides and lincosamides, the tested strains showed reduced sensitivity, the dominant resistance phenotype being the inducible one. Regarding aminoglycosides, 45.9% of all analyzed strains were resistant to tobramycin, 39.3% to gentamicin and 13.7% to amikacin. The strains showed increased resistance to tetracycline (48.2%) and ciprofloxacin (42.1%), and reduced resistance to linezolid (1.6%). All strains tested were susceptible to vancomycin.

Conclusions. Methicillin-resistant strains represented 59.0% of the strains tested. Vancomycin and linezolid are the drugs that remain to be indicated in the empiric treatment of severe infections caused by S. aureus.